Trajectories of body mass index in adulthood and risk of subtypes of postmenopausal breast cancer.

ABSTRACT:

Background

Body fatness is a dynamic exposure throughout life. To provide more insight into the association between body mass index (BMI) and postmenopausal breast cancer, we aimed to examine the age at onset, duration, intensity, and trajectories of body fatness in adulthood in relation to risk of breast cancer subtypes.

Methods

Based on self-reported anthropometry in the prospective Norwegian Women and Cancer Study, we calculated the age at onset, duration, and intensity of overweight and obesity using linear mixed-effects models. BMI trajectories in adulthood were modeled using group-based trajectory modeling. We used Cox proportional hazards models to calculate hazard ratios (HRs) with 95% confidence intervals (CIs) for the associations between BMI exposures and breast c

SUBMITTER: Busund M 

PROVIDER: S-EPMC10612168 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature