Integration of machine learning to identify diagnostic genes in leukocytes for acute myocardial infarction patients.

ABSTRACT:

Background

Acute myocardial infarction (AMI) has two clinical characteristics: high missed diagnosis and dysfunction of leukocytes. Transcriptional RNA on leukocytes is closely related to the course evolution of AMI patients. We hypothesized that transcriptional RNA in leukocytes might provide potential diagnostic value for AMI. Integration machine learning (IML) was first used to explore AMI discrimination genes. The following clinical study was performed to validate the results.

Methods

A total of four AMI microarrays (derived from the Gene Expression Omnibus) were included in bioanalysis (220 sample size). Then, the clinical validation was finished with 20 AMI and 20 stable coronary artery disease patients (SCAD). At a ratio of 5:2, GSE59867 was included in the training s

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10612217 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature