CD28/PD1 co-expression: dual impact on CD8⁺ T cells in peripheral blood and tumor tissue, and its significance in NSCLC patients' survival and ICB response.

ABSTRACT:

Background

Immune checkpoint blockade (ICB) has significantly prolonged survival of non-small cell lung cancer (NSCLC) patients, although most patients develop mechanisms of resistance. Recently single-cell RNA-sequencing (scRNA-Seq) revealed a huge T-cell phenotypic and (dys)functional state variability. Accordingly, T-cell exhaustion is recognized as a functional adaptation, with a dynamic progression from a long-lived "pre-exhausted stem-like progenitor" to a "terminally exhausted" state. In this scenario it is crucial to understand the complex interplay between co-stimulatory and inhibitory molecules in CD8⁺ T-cell functionality.

Methods

To gain a baseline landscape of the composition, functional states, and transcriptomic signatures predictive of prognosis, w

SUBMITTER: Palermo B 

PROVIDER: S-EPMC10612243 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature