Meningioma animal models: a systematic review and meta-analysis.

ABSTRACT:

Background

Animal models are widely used to study pathological processes and drug (side) effects in a controlled environment. There is a wide variety of methods available for establishing animal models depending on the research question. Commonly used methods in tumor research include xenografting cells (established/commercially available or primary patient-derived) or whole tumor pieces either orthotopically or heterotopically and the more recent genetically engineered models-each type with their own advantages and disadvantages. The current systematic review aimed to investigate the meningioma model types used, perform a meta-analysis on tumor take rate (TTR), and perform critical appraisal of the included studies. The study also aimed to assess reproducibility, reliability, mean

SUBMITTER: Andersen MS 

PROVIDER: S-EPMC10612271 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature