Should IUI replace IVF as first-line treatment for unexplained infertility? A literature review.

ABSTRACT:

Background

Unexplained infertility accounts for 25% of infertility causes in the UK. Active intervention methods, such as intrauterine insemination (IUI) or in vitro fertilisation (IVF), are often sought. Despite the National Institute for Health and Care Excellence (NICE) recommending IVF for unexplained infertility, this recommendation has generated an ongoing debate, with few fertility clinics discontinuing the use of IUI as the first-line management of choice. In contrast to NICE, recent guidance released from the European Society for Human Reproduction and Embryology (ESHRE) in August 2023 supports the use of IUI as first-line. High-quality evidence behind such interventions is lacking, with current literature providing conflicting results.

Aims

This review aims to prov

SUBMITTER: Man JK 

PROVIDER: S-EPMC10612289 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature