Profound DNA methylomic differences between single- and multi-fraction alpha irradiations of lung fibroblasts.

ABSTRACT:

Background

Alpha (α)-radiation is a ubiquitous environmental agent with epigenotoxic effects. Human exposure to α-radiation at potentially harmful levels can occur repetitively over the long term via inhalation of naturally occurring radon gas that accumulates in enclosed spaces, or as a result of a single exposure from a nuclear accident. Alterations in epigenetic DNA methylation (DNAm) have been implicated in normal aging and cancer pathogenesis. Nevertheless, the effects of aberrations in the methylome of human lung cells following exposure to single or multiple α-irradiation events on these processes remain unexplored.

Results

We performed genome-wide DNAm profiling of human embryonic lung fibroblasts from control and irradiated cells using americium-241 α-sources. Cells

SUBMITTER: Vera-Chang MN 

PROVIDER: S-EPMC10612361 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature