Discordant Biological and Chronological Age: Implications for Cognitive Decline and Frailty.

ABSTRACT:

Background

Older adults with discordant biological and chronological ages (BA and CA) may vary in cognitive and physical function from those with concordant BA and CA.

Methods

To make our approach clinically accessible, we created easy-to-interpret participant groups in the Health, Aging, and Body Composition Study (N = 2 458, 52% female participants, 65% White participants, age: 73.5 ± 2.8) based on medians of CA, and a previously validated BA index comprised of readily available clinical tests. Joint models estimated associations of BA-CA group with cognition (Modified Mini-Mental State Examination [3MS] and Digit Symbol Substitution Test [DSST]) and frailty over 10 years.

Results

The sample included the following: 32%, Young group (BA and CA < median); 21%, Prematu

SUBMITTER: Shaaban CE 

PROVIDER: S-EPMC10613009 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature