Thermal Therapy Modulation of the Psoriasis-Associated Skin and Gut Microbiome.

ABSTRACT:

Introduction

Psoriasis is a systemic immune-mediated disease primarily manifesting as skin redness and inflammation. Balneotherapy proved to be a successful non-pharmacological option to reduce the skin areas affected by the disease, but the specific mechanisms underlying this effect have not been elucidated yet. Here we test the hypothesis that the effect of thermal treatments on psoriatic lesions could be partially mediated by changes in the resident microbial population, i.e., the microbiome.

Methods

In this study, we enrolled patients with psoriasis and monitored changes in their skin and gut microbiome after a 12-bath balneotherapy course with a combination of 16S rRNA amplicon sequencing and metagenomics. Changes in the resident microbiome were then correlated with the

SUBMITTER: Manara S 

PROVIDER: S-EPMC10613183 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature