Evaluating the Appropriateness of Existing Health-Related Quality of Life Measures in Lichen Planus.

ABSTRACT:

Introduction

Lichen planus (LP) is an inflammatory skin disorder that can present in various forms across the body, including lesions on the skin (cutaneous LP [CLP]), scalp (lichen planopilaris [LPP]) and mucosal regions (mucosal LP [MLP]). Several existing patient-reported outcome measures (PROMs) were identified for potential use in LP clinical development programs. This study aimed to assess the content validity and psychometric measurement properties of the Dermatology Life Quality Index (DLQI), Epworth Sleepiness Scale (ESS), Scalpdex and Oral Lichen Planus Symptom Severity Measure (OLPSSM) in an LP population.

Methods

Patients completed the PROs at various time points as part of an international Phase 2 clinical study in adults with MLP (n = 37), LPP (n = 37) and CLP

SUBMITTER: Mahon-Smith A 

PROVIDER: S-EPMC10613190 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature