Functional connectivity between the amygdala and prefrontal cortex underlies processing of emotion ambiguity.

ABSTRACT: Processing facial expressions of emotion draws on a distributed brain network. In particular, judging ambiguous facial emotions involves coordination between multiple brain areas. Here, we applied multimodal functional connectivity analysis to achieve network-level understanding of the neural mechanisms underlying perceptual ambiguity in facial expressions. We found directional effective connectivity between the amygdala, dorsomedial prefrontal cortex (dmPFC), and ventromedial PFC, supporting both bottom-up affective processes for ambiguity representation/perception and top-down cognitive processes for ambiguity resolution/decision. Direct recordings from the human neurosurgical patients showed that the responses of amygdala and dmPFC neurons were modulated by the level of emotion ambiguit

SUBMITTER: Sun S 

PROVIDER: S-EPMC10613296 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature