Salicylate induces AMPK and inhibits c-MYC to activate a NRF2/ARE/miR-34a/b/c cascade resulting in suppression of colorectal cancer metastasis.
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ABSTRACT:
SUBMITTER: Liu C
PROVIDER: S-EPMC10613307 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
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Salicylate induces AMPK and inhibits c-MYC to activate a NRF2/ARE/miR-34a/b/c cascade resulting in suppression of colorectal cancer metastasis.
Liu Chunfeng C Rokavec Matjaz M Huang Zekai Z Hermeking Heiko H
Cell death & disease 20231028 10
Aspirin and its active metabolite salicylate have emerged as promising agents for the chemoprevention of colorectal cancer (CRC). Moreover, aspirin suppresses the progression of established CRCs. However, the underlying molecular mechanisms are not completely understood. Here we found that salicylate induces the expression of the miR-34a and miR-34b/c genes, which encode tumor suppressive microRNAs, in a p53-independent manner. Salicylate activated AMPK, thereby activating NRF2, which directly i ...[more]
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