Regulation of Proteins to the Cytosol Using Delivery Systems with Engineered Polymer Architecture.

ABSTRACT: Intracellular protein delivery enables selective regulation of cellular metabolism, signaling, and development through introduction of defined protein quantities into the cell. Most applications require that the delivered protein has access to the cytosol, either for protein activity or as a gateway to other organelles such as the nucleus. The vast majority of delivery vehicles employ an endosomal pathway however, and efficient release of entrapped protein cargo from the endosome remains a challenge. Recent research has made significant advances toward efficient cytosolic delivery of proteins using polymers, but the influence of polymer architecture on protein delivery is yet to be investigated. Here, we developed a family of dendronized polymers that enable systematic alterations of charg

SUBMITTER: Kretzmann JA 

PROVIDER: S-EPMC10613456 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature