Evaluation of isocitrate dehydrogenase mutation in 2021 world health organization classification grade 3 and 4 glioma adult-type diffuse gliomas with 18F-fluoromisonidazole PET.

ABSTRACT:

Purpose

This study aimed to investigate the uptake characteristics of ¹⁸F-fluoromisonidazole (FMISO), in mutant-type isocitrate dehydrogenase (IDH-mutant, grade 3 and 4) and wild-type IDH (IDH-wildtype, grade 4) 2021 WHO classification adult-type diffuse gliomas.

Materials and methods

Patients with grade 3 and 4 adult-type diffuse gliomas (n = 35) were included in this prospective study. After registering ¹⁸F-FMISO PET and MR images, standardized uptake value (SUV) and apparent diffusion coefficient (ADC) were evaluated in hyperintense areas on fluid-attenuated inversion recovery (FLAIR) imaging (HIA), and in contrast-enhanced tumors (CET) by manually placing 3D volumes of interest. Relative SUV_max (rSUV_max) and SUV_mean

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10613590 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature