Modification of astrocytic Cx43 hemichannel activity in animal models of AD: modulation by adenosine A_2A receptors.

ABSTRACT: Increasing evidence implicates astrocytic dysfunction in Alzheimer's disease (AD), a neurodegenerative disorder characterised by progressive cognitive loss. The accumulation of amyloid-β (Aβ) plaques is a histopathological hallmark of AD and associated with increased astrocyte reactivity. In APP/PS1 mice modelling established AD (9 months), we now show an altered astrocytic morphology and enhanced activity of astrocytic hemichannels, mainly composed by connexin 43 (Cx43). Hemichannel activity in hippocampal astrocytes is also increased in two models of early AD: (1) mice with intracerebroventricular (icv) administration of Aβ_1-42, and (2) hippocampal slices superfused with Aβ_1-42 peptides. In hippocampal gliosomes of APP/PS1 mice, Cx43 levels were increased, whereas m

SUBMITTER: Madeira D 

PROVIDER: S-EPMC10613596 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature