Unraveling the connection between gut microbiota and Alzheimer's disease: a two-sample Mendelian randomization analysis.

ABSTRACT:

Purpose

Studies have shown a close relationship between gut microbiota (GM) and Alzheimer's disease (AD). However, the causal relationship between them remains unclear.

Methods

We conducted a genome-wide association study (GWAS) using publicly available summary statistics data for GM and AD. We extracted independent genetic loci significantly associated with GM relative abundances as instrumental variables based on predefined thresholds (p < 1*e-5). The inverse variance-weighted (IVW) method was primarily used for causal relationship assessment. Additional analyses, including MR-Egger, weighted median, simple mode, and weighted mode, were performed as supplementary analyses.

Results

IVW analysis revealed significant correlations between certain microbial taxa a

SUBMITTER: Zeng H 

PROVIDER: S-EPMC10613649 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature