Thyroid hormone sensitivity and diabetes onset: a longitudinal cross-lagged cohort.

ABSTRACT:

Purpose

Thyroid hormones sensitivity is a newly proposed clinical entity closely related with metabolic health. Prior studies have reported the cross-sectional relationship between thyroid hormones sensitivity and diabetes; however, the longitudinal association is unclear to date. We aimed to explore the relationship between impaired thyroid hormone sensitivity at baseline and diabetes onset using a cohort design.

Methods

This study enrolled 7283 euthyroid participants at the first visit between 2008 and 2009, and then annually followed until diabetes onset or 2019. Thyrotropin (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) were measured to calculate thyroid hormone sensitivity by thyroid feedback quantile-based index (TFQI), Chinese-referenced parametric thyroi

SUBMITTER: Cui C 

PROVIDER: S-EPMC10613705 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature