Insulin Preferentially Regulates the Activity of Parasympathetic Preganglionic Neurons over Sympathetic Preganglionic Neurons.

ABSTRACT:

Backgruound

Insulin is a peptide hormone that regulates post-prandial physiology, and it is well known that insulin controls homeostasis at least in part via the central nervous system. In particular, insulin alters the activity of neurons within the autonomic nervous system. However, currently available data are mostly from unidentified brainstem neurons of the dorsal motor nucleus of the vagus nerve (DMV).

Methods

In this study, we used several genetically engineered mouse models to label distinct populations of neurons within the brainstem and the spinal cord for whole-cell patch clamp recordings and to assess several in vivo metabolic functions.

Results

We first confirmed that insulin directly inhibited cholinergic (parasympathetic preganglionic) neurons in the DM

SUBMITTER: Hyun U 

PROVIDER: S-EPMC10613773 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature