N-terminal pro atrial natriuretic peptide as a prognostic marker of cardiac resynchronization therapy recipients.

ABSTRACT:

Background

Although the dynamic changes of atrial natriuretic peptide (ANP) expressions in a failing heart are well-documented, the clinical implications of detailed measurements of each ANP molecular form processed from proANP remain unclear.

Methods

Patients screening was conducted on patients who were eligible for cardiac resynchronization therapy (CRT) between 2014 and 2019 in our institution. Blood samples and echocardiographic parameters were collected on the day before and six months after implantation. Total ANP, proANP, and N-terminal fragment of proANP (NT-proANP) were examined as predictive biomarkers for cardiac death, left ventricular assist device implantation, and heart failure hospitalization following CRT implantation.

Results

A total of 86 subjects (

SUBMITTER: Ueda N 

PROVIDER: S-EPMC10613895 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature