Social withdrawal and anxiety-like behavior have an impact on zebrafish adult neurogenesis.

ABSTRACT:

Introduction

Accumulating evidence highlights the key role of adult neurogenesis events in environmental challenges, cognitive functions and mood regulation. Abnormal hippocampal neurogenesis has been implicated in anxiety-like behaviors and social impairments, but the possible mechanisms remain elusive.

Methods

The present study questioned the contribution of altered excitation/inhibition as well as excessive neuroinflammation in regulating the neurogenic processes within the Social Decision-Making (SDM) network, using an adult zebrafish model displaying NMDA receptor hypofunction after sub-chronic MK-801 administration. For this, the alterations in cell proliferation and newborn cell densities were evaluated using quantitative 5-Bromo-2'-Deoxyuridine (BrdU) methodology.

SUBMITTER: Perdikaris P 

PROVIDER: S-EPMC10614005 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature