Dolutegravir and pregnancy outcomes including neural tube defects in the USA during 2008-20: a national cohort study.

ABSTRACT:

Background

A study from Botswana identified an increased risk of neural tube defects (NTDs) in infants of mothers with HIV who were treated with dolutegravir around the time of conception. We aimed to examine associations of dolutegravir use with NTDs and pregnancy loss using large health-care claims databases from the USA, a country with folic acid fortification of food.

Methods

In this cohort study, we analysed health-care claims data, recorded in the Merative MarketScan commercial database (MarketScan data) and Centers for Medicare & Medicaid Services Medicaid database (Medicaid data) from Jan 1, 2008, to Dec 31, 2020. We identified pregnancies with enrolment during their entire duration among women aged 15-49 years and we estimated time of conception. For each pregnancy,

SUBMITTER: Kourtis AP 

PROVIDER: S-EPMC10614030 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature