Association of DCIS size and margin status with risk of developing breast cancer post-treatment: multinational, pooled cohort study.

ABSTRACT:

Objective

To examine the association between size and margin status of ductal carcinoma in situ (DCIS) and risk of developing ipsilateral invasive breast cancer and ipsilateral DCIS after treatment, and stage and subtype of ipsilateral invasive breast cancer.

Design

Multinational, pooled cohort study.

Setting

Four large international cohorts.

Participants

Patient level data on 47 695 women with a diagnosis of pure, primary DCIS between 1999 and 2017 in the Netherlands, UK, and US who underwent surgery, either breast conserving or mastectomy, often followed by radiotherapy or endocrine treatment, or both.

Main outcome measures

The main outcomes were 10 year cumulative incidence of ipsilateral invasive breast cancer and ipsilateral DCIS estimated in relati

SUBMITTER: Schmitz RSJM 

PROVIDER: S-EPMC10614034 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature