Optimizing diabetic kidney disease animal models: Insights from a meta-analytic approach.

ABSTRACT: Diabetic kidney disease (DKD) is a prevalent complication of diabetes, often leading to end-stage renal disease. Animal models have been widely used to study the pathogenesis of DKD and evaluate potential therapies. However, current animal models often fail to fully capture the pathological characteristics of renal injury observed in clinical patients with DKD. Additionally, modeling DKD is often a time-consuming, costly, and labor-intensive process. The current review aims to summarize modeling strategies in the establishment of DKD animal models by utilizing meta-analysis related methods and to aid in the optimization of these models for future research. A total of 1215 articles were retrieved with the keywords of "diabetic kidney disease" and "animal experiment" in the past 10 years. Fo

SUBMITTER: Li F 

PROVIDER: S-EPMC10614131 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature