Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia in middle-income countries.

ABSTRACT:

Background

Adenovirus-based COVID-19 vaccines are extensively used in low- and middle-income countries (LMICs). Remarkably, cases of cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) have rarely been reported from LMICs.

Aims

We studied the frequency, manifestations, treatment, and outcomes of CVST-VITT in LMICs.

Methods

We report data from an international registry on CVST after COVID-19 vaccination. VITT was classified according to the Pavord criteria. We compared CVST-VITT cases from LMICs to cases from high-income countries (HICs).

Results

Until August 2022, 228 CVST cases were reported, of which 63 were from LMICs (all middle-income countries [MICs]: Brazil, China, India, Iran, Mexico, Pakistan, Turkey).

SUBMITTER: van de Munckhof A 

PROVIDER: S-EPMC10614174 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature