Identification and Validation of an Aging-Associated circRNA-miRNA-mRNA Network in Neovascular Age-Related Macular Degeneration.

ABSTRACT:

Introduction

Neovascular age-related macular degeneration (NVAMD) is a leading cause of severe vision impairment in the elderly. Aging is one of the most pivotal underlying molecular mechanisms of NVAMD.

Methods

In this study, we identified the potential aging-related genes involved in NVAMD. Considering that noncoding RNAs are vital regulators of NVAMD progression, we further explored and constructed an aging-originated circRNA-miRNA-mRNA network of NVAMD. Differential expression of 23 aging-associated genes was identified based on sequencing data and the Human Aging Genomic Resources tool at a threshold of p < 0.05, and log2|fold change| > 1.

Results

We screened 12 microRNAs (miRNAs) using public datasets and miRNet database. A total of 13 circRNAs were subseq

SUBMITTER: Wu J 

PROVIDER: S-EPMC10614246 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature