Distinct temporal trajectories and risk factors for Post-acute sequelae of SARS-CoV-2 infection.

ABSTRACT:

Background

The understanding of Post-acute sequelae of SARS-CoV-2 infection (PASC) can be improved by longitudinal assessment of symptoms encompassing the acute illness period. To gain insight into the various disease trajectories of PASC, we assessed symptom evolution and clinical factors associated with the development of PASC over 3 months, starting with the acute illness period.

Methods

We conducted a prospective cohort study to identify parameters associated with PASC. We performed cluster and case control analyses of clinical data, including symptomatology collected over 3 months following infection.

Results

We identified three phenotypic clusters associated with PASC that could be characterized as remittent, persistent, or incident based on the 3-month change i

SUBMITTER: Chen C 

PROVIDER: S-EPMC10614284 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature