Identification of novel circulating miRNAs biomarkers for healthy obese and lean children.

ABSTRACT:

Background

The prevalence of childhood obesity and overweight has risen globally, leading to increased rates of metabolic disorders. Various factors, including genetic, epigenetic, and environmental influences such as diet and physical activity, contribute to pediatric obesity. This study aimed to identify specific circulating miRNAs as potential biomarkers for assessing obesity in children.

Methods

Thirty children, including 15 obese and 15 extremely thin individuals, were selected for this study. MiRNA expression in circulating plasma was assessed using miRNA microarrays. The reliability of differential miRNA expression was confirmed using TaqMan qPCR. The correlation between miRNAs and obesity was analyzed through multiple linear regression, receiver operator characterist

SUBMITTER: Ma F 

PROVIDER: S-EPMC10614305 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature