Infectious bursal disease virus: predicting viral pathotype using machine learning models focused on early changes in total blood cell counts.

ABSTRACT: Infectious bursal disease (IBD) is an avian viral disease caused in chickens by infectious bursal disease virus (IBDV). IBDV strains (Avibirnavirus genus, Birnaviridae family) exhibit different pathotypes, for which no molecular marker is available yet. The different pathotypes, ranging from sub-clinical to inducing immunosuppression and high mortality, are currently determined through a 10-day-long animal experiment designed to compare mortality and clinical score of the uncharacterized strain with references strains. Limits of this protocol lie within standardization and the extensive use of animal experimentation. The aim of this study was to establish a predictive model of viral pathotype based on a minimum number of early parameters measured during infection, allowing faster pathotypi

SUBMITTER: Molinet A 

PROVIDER: S-EPMC10614337 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature