Blockade of adenosine A_2A receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer's disease by promoting synaptic plasticity of adult-born granule cells.

ABSTRACT:

Background

The over-activation of adenosine A_2A receptors (A_2AR) is closely implicated in cognitive impairments of Alzheimer's disease (AD). Growing evidence shows that A_2AR blockade possesses neuroprotective effects on AD. Spatial navigation impairment is an early manifestation of cognitive deficits in AD. However, whether A_2AR blockade can prevent early impairments in spatial cognitive function and the underlying mechanism is still unclear.

Methods

A transgenic APP/PS1 mouse model of AD amyloidosis was used in this study. Behavioral tests were conducted to observe the protective effects of A_2AR blockade on early spatial memory deficits in 4-month old APP/PS1 mice. To investigate the underlying synaptic mechanism of the

SUBMITTER: Ji Q 

PROVIDER: S-EPMC10614339 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature