Intracellular remodeling associated with endoplasmic reticulum stress modifies biomechanical compliance of bladder cells.

ABSTRACT: Bladder cells face a challenging biophysical environment: mechanical cues originating from urine flow and regular contraction to enable the filling voiding of the organ. To ensure functional adaption, bladder cells rely on high biomechanical compliance, nevertheless aging or chronic pathological conditions can modify this plasticity. Obviously the cytoskeletal network plays an essential role, however the contribution of other, closely entangled, intracellular organelles is currently underappreciated. The endoplasmic reticulum (ER) lies at a crucial crossroads, connected to both nucleus and cytoskeleton. Yet, its role in the maintenance of cell mechanical stability is less investigated. To start exploring these aspects, T24 bladder cancer cells were treated with the ER stress inducers brefe

SUBMITTER: Gruber L 

PROVIDER: S-EPMC10614373 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature