Prevention of severe lung immunopathology associated with influenza infection through adeno-associated virus vector administration.

ABSTRACT:

Background

Influenza A viruses (IAVs) have long posed a threat to humans, occasionally causing significant morbidity and mortality. The initial immune response is triggered by infected epithelial cells, alveolar macrophages and dendritic cells. However, an exaggerated innate immune response can result in severe lung injury and even host mortality. One notable pathology observed in hosts succumbing to severe influenza is the excessive influx of neutrophils and monocytes into the lung. In this study, we investigated a strategy for controlling lung immunopathology following severe influenza infection.

Results

To evaluate the impact of innate immunity on influenza-associated lung injury, we employed CB17.SCID and NOD.SCID mice. NOD.SCID mice exhibited slower weight loss and long

SUBMITTER: Choi EA 

PROVIDER: S-EPMC10614381 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature