Efficient production of mycosporine-like amino acids, natural sunscreens, in Yarrowia lipolytica.

ABSTRACT:

Background

Mycosporine-like amino acids (MAAs), including shinorine and porphyra-334, are gaining attention as safe natural sunscreens. The production of MAAs has been achieved in diverse microbial hosts, including Saccharomyces cerevisiae. While S. cerevisiae is the most extensively studied model yeast, the oleaginous yeast Yarrowia lipolytica has emerged as a promising candidate for the synthesis of valuable products. In this study, we explored the potential of Y. lipolytica as a host for producing MAAs, utilizing its advantages such as a robust pentose phosphate pathway flux and versatile carbon source utilization.

Results

We produced MAAs in Y. lipolytica by introducing the MAA biosynthetic genes from cyanobacteria Nostoc punctiforme and Anabaena variabilis. These genes

SUBMITTER: Jin H 

PROVIDER: S-EPMC10614408 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature