Detection and analysis of endogenous polar volatile organic compounds (PVOCs) in urine for human exposome research.

ABSTRACT: Background: The human exposome, defined as '…everything that is not the genome', comprises all chemicals in the body interacting with life processes. The exposome drives genes x environment (GxE) interactions that can cause long-term latency and chronic diseases. The exposome constantly changes in response to external exposures and internal metabolism. Different types of compounds are found in different biological media. Objective: Measure polar volatile organic compounds (PVOCs) excreted in urine to document endogenous metabolites and exogenous compounds from environmental exposures. Methods: Use headspace collection and sorbent tube thermal desorption coupled with bench-top gas chromatography-mass spectrometry (GC-MS) for targeted and non-targeted approaches.

SUBMITTER: O'Lenick CR 

PROVIDER: S-EPMC10614422 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature