Sex-specific analysis in Behcet's disease reveals higher genetic risk in male patients.

ABSTRACT:

Objectives

Behçet's disease tends to be more severe in men than women. This study was undertaken to investigate sex-specific genetic effects in Behçet's disease.

Methods

A total of 1762 male and 1216 female patients with Behçet's disease from six diverse populations were studied, with the majority of patients of Turkish origin. Genotyping was performed using an Infinium ImmunoArray-24 BeadChip, or extracted from available genotyping data. Following imputation and extensive quality control measures, genome-wide association analysis was performed comparing male to female patients in the Turkish cohort, followed by a meta-analysis of significant results in all six populations. In addition, a weighted genetic risk score for Behçet's disease was calculated and compared between ma

SUBMITTER: Jo YG 

PROVIDER: S-EPMC10614427 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature