Molecular and Functional Heterogeneity of Primary Pancreatic Neuroendocrine Tumors and Metastases.

ABSTRACT:

Introduction

Treatment response to the standard therapy is low for metastatic pancreatic neuroendocrine tumors (PanNETs) mainly due to the tumor heterogeneity. We investigated the heterogeneity between primary PanNETs and metastases to improve the precise treatment.

Methods

The genomic and transcriptomic data of PanNETs were retrieved from the Genomics, Evidence, Neoplasia, Information, Exchange (GENIE), and Gene Expression Omnibus (GEO) database, respectively. Potential prognostic effects of gene mutations enriched in metastases were investigated. Gene set enrichment analysis was performed to investigate the functional difference. Oncology Knowledge Base was interrogated for identifying the targetable gene alterations.

Results

Twenty-one genes had significantly highe

SUBMITTER: Guo Y 

PROVIDER: S-EPMC10614458 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature