Puerarin alleviates inflammation and pathological damage in colitis mice by regulating metabolism and gut microbiota.

ABSTRACT: Dysbiosis of gut microbiota and metabolic pathway disorders are closely related to the ulcerative colitis. Through network pharmacology, we found that puerarin is a potential ingredient that can improve the crypt deformation and inflammatory infiltration in mice, and decrease the levels of IL-1β, IL-6 and TNF-α significantly. Listeria, Alistipes and P. copri gradually became dominant bacteria in UC mice, which were positively correlated with inflammatory factors. Puerarin effectively improved dysbiosis by reducing the abundance of Alistipes, P. copri and Veillonella, and increasing the level of Desulfovibrionacea. Correlation network and metabolic function prediction analysis of the microbiota showed that they formed a tightly connected netw

SUBMITTER: Zou Y 

PROVIDER: S-EPMC10614640 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature