Changes in lipid profiles of epileptic mouse model.

ABSTRACT:

Introduction

Approximately 1% of the world's population is impacted by epilepsy, a chronic neurological disorder characterized by seizures. One-third of epileptic patients are resistant to AEDs, or have medically refractory epilepsy (MRE). One non-invasive treatment that exists for MRE includes the ketogenic diet, a high-fat, low-carbohydrate diet. Despite the KD's success in seizure attenuation, it has a few risks and its mechanisms remain poorly understood. The KD has been shown to improve metabolism and mitochondrial function in epileptic phenotypes. Potassium channels have implications in epileptic conditions as they have dual roles as metabolic sensors and control neuronal excitation.

Objectives

The goal of this study was to explore changes in the lipidome in hippocampa

SUBMITTER: Johnson A 

PROVIDER: S-EPMC10614666 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature