Piezo1 specific deletion in macrophage protects the progression of liver fibrosis in mice.

ABSTRACT: Background and Aims: Liver fibrosis is the common pathological pathway of chronic liver diseases and its mechanisms of which have not been fully declared. Macrophages play essential roles in progression of liver fibrosis partially by sensing abnormal mechanical signals. The aim of the study is to investigate the functions of macrophage Piezo1, a mechano-sensitive ion channel, in liver fibrosis. Approach and Results: Immunofluorescence in human and murine fibrotic liver samples revealed that expression of macrophage Piezo1 was increased. Myeloid-specific Piezo1 knockout (Piezo1^ΔLysM) attenuated liver fibrosis by decreased collagen deposition and epithelial-mesenchymal transition (EMT). In Piezo1^ΔLysM mice, less inflammation during dev

SUBMITTER: Luo S 

PROVIDER: S-EPMC10614683 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature