Upregulated FOXM1 stimulates chondrocyte senescence in Acot12^-/-Nudt7^-/- double knockout mice.

ABSTRACT: Rationale: One of the hallmarks of osteoarthritis (OA), the most common degenerative joint disease, is increased numbers of senescent chondrocytes. Targeting senescent chondrocytes or signaling mechanisms leading to senescence could be a promising new therapeutic approach for OA treatment. However, understanding the key targets and links between chondrocyte senescence and OA remains unclear. Methods: Senescent chondrocytes were identified from Nudt7^-/-, Acot12^-/-, double-knockout mice lacking Acot12 and Nudt7 (dKO) and applied to microarray. The presence of forkhead transcription factor M1 (FOXM1) was detected in aged, dKO, and destabilization of the medial meniscus (DMM) cartilages and articular chondrocytes, and the effect of Fo

SUBMITTER: Song J 

PROVIDER: S-EPMC10614692 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature