Cortical tau is associated with microstructural imaging biomarkers of neurite density and dendritic complexity in Alzheimer's disease.

ABSTRACT:

Introduction

In Alzheimer's disease (AD), hyperphosphorylated tau is closely associated with focal neurodegeneration, but the mechanism remains uncertain.

Methods

We quantified cortical microstructure using neurite orientation dispersion and density imaging in 14 individuals with young onset AD. Diffusion tensor imaging measured mean diffusivity (MD). Amyloid beta and tau positron emission tomography were acquired and associations with microstructural measures were assessed.

Results

When regional volume was adjusted for, in the medial temporal lobe there was a significant negative association between neurite density and tau (partial R²  = 0.56, p = 0.008) and between orientation dispersion and tau (partial R²  = 0.66, p = 0.002), but not between

SUBMITTER: Weston PSJ 

PROVIDER: S-EPMC10614698 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature