NODDI-derived measures of microstructural integrity in medial temporal lobe white matter pathways are associated with Alzheimer's disease pathology and cognitive outcomes.

ABSTRACT:

Introduction

Diffusion tensor imaging has been used to assess white matter (WM) changes in the early stages of Alzheimer's disease (AD). However, the tensor model is necessarily limited by its assumptions. Neurite Orientation Dispersion and Density Imaging (NODDI) can offer insights into microstructural features of WM change. We assessed whether NODDI more sensitively detects AD-related changes in medial temporal lobe WM than traditional tensor metrics.

Methods

Standard diffusion and NODDI metrics were calculated for medial temporal WM tracts from 199 older adults drawn from ADNI3 who also received PET to measure pathology and neuropsychological testing.

Results

NODDI measures in medial temporal tracts were more strongly correlated to cognitive performance and patholo

SUBMITTER: Parker DM 

PROVIDER: S-EPMC10614746 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature