Clinically relevant humanized mouse models of metastatic prostate cancer to evaluate cancer therapies.

ABSTRACT: There is tremendous need for improved prostate cancer (PCa) models. The mouse prostate does not spontaneously form tumors and is anatomically and developmentally different from the human prostate. Engineered mouse models lack the heterogeneity of human cancer and rarely establish metastatic growth. Human xenografts represent an alternative but rely on an immunocompromised host. Accordingly, we generated PCa murine xenograft models with an intact human immune system (huNOG and huNOG-EXL mice) to test whether humanizing tumor-immune interactions would improve modeling of metastatic PCa and the impact of hormonal and immunotherapies. These mice maintain multiple human cell lineages, including functional human T-cells and myeloid cells. In 22Rv1 xenografts, subcutaneous tumor size was not sign

SUBMITTER: Kostlan RJ 

PROVIDER: S-EPMC10614761 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature