Dynamics of Neutrophilia at the Neurovascular Unit Arising from Repeated Pulmonary Inflammation.

ABSTRACT:

Background

The role of neutrophils in mediating neurovascular vulnerability has been increasingly implicated in various acute inflammatory models of neuroimmune crosstalk between the periphery and the brain. Whether neurovascular vulnerability is similarly modulated in the context of frequent, but not acute, inflammatory activation in the periphery is the aim of our study. Such a model of frequent inflammatory irritation is pertinent to understanding the neurologic risk of constant exposure to aerosolized environmental hazards leading to progressive pulmonary disease.

Methods

To model repeated pulmonary inflammation, we applied a three-dose regimen of intranasal (i.n.) lipopolysaccharide (LPS) in C57BL/6J mice and studied the impact on the inflammatory environment of the bra

SUBMITTER: Chiang W 

PROVIDER: S-EPMC10614777 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature