The NFκB <i>Dif</i> is required for behavioral and molecular correlates of sleep homeostasis in <i>Drosophila</i>.

ABSTRACT: The nuclear factor binding the κ light chain in B-cells (NFκB) is involved in a wide range of cellular processes including development, growth, innate immunity, and sleep. However, efforts have been limited toward understanding how specific NFκB transcription factors function in sleep. Drosophila fruit flies carry three genes encoding NFκB transcription factors, Dorsal, Dorsal Immunity Factor (Dif), and Relish. We previously found that loss of the Relish gene from fat body suppressed daily nighttime sleep, and abolished infection-induced sleep. Here we show that Dif regulates daily sleep and recovery sleep following prolonged wakefulness. Mutants of Dif showed reduced daily sleep and suppressed recovery in response to sleep deprivatio

SUBMITTER: O'Hara MK 

PROVIDER: S-EPMC10614778 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature