Interactions between ploidy and resource availability shape clonal interference at initiation and recurrence of glioblastoma.

ABSTRACT: Glioblastoma (GBM) is the most aggressive form of primary brain tumor. Complete surgical resection of GBM is almost impossible due to the infiltrative nature of the cancer. While no evidence for recent selection events have been found after diagnosis, the selective forces that govern gliomagenesis are strong, shaping the tumor's cell composition during the initial progression to malignancy with late consequences for invasiveness and therapy response. We present a mathematical model that simulates the growth and invasion of a glioma, given its ploidy level and the nature of its brain tissue micro-environment (TME), and use it to make inferences about GBM initiation and response to standard-of-care treatment. We approximate the spatial distribution of resource access in the TME through integ

SUBMITTER: Nowicka Z 

PROVIDER: S-EPMC10614845 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature