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Spatiotemporally-specific cortical-subthalamic coupling differentiates aspects of speech performance.


ABSTRACT: Speech provides a rich context for exploring human cortical-basal ganglia circuit function, but direct intracranial recordings are rare. We recorded electrocorticographic signals in the cortex synchronously with single units in the subthalamic nucleus (STN), a basal ganglia node that receives direct input from widespread cortical regions, while participants performed a syllable repetition task during deep brain stimulation (DBS) surgery. We discovered that STN neurons exhibited spike-phase coupling (SPC) events with distinct combinations of frequency, location, and timing that indexed specific aspects of speech. The strength of SPC to posterior perisylvian cortex predicted phoneme production accuracy, while that of SPC to perirolandic cortex predicted time taken for articulation Thus, STN-cortical interactions are coordinated via transient bursts of behavior-specific synchronization that involves multiple neuronal populations and timescales. These results both suggest mechanisms that support auditory-sensorimotor integration during speech and explain why firing-rate based models are insufficient for explaining basal ganglia circuit behavior.

SUBMITTER: Vissani M 

PROVIDER: S-EPMC10614892 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Spike-phase coupling of subthalamic neurons to posterior opercular cortex predicts speech sound accuracy.

Vissani Matteo M   Bush Alan A   Lipski Witold J WJ   Bullock Latané L   Fischer Petra P   Neudorfer Clemens C   Holt Lori L LL   Fiez Julie A JA   Turner Robert S RS   Richardson R Mark RM   Richardson R Mark RM  

bioRxiv : the preprint server for biology 20240702


Speech provides a rich context for understanding how cortical interactions with the basal ganglia contribute to unique human behaviors, but opportunities for direct intracranial recordings across cortical-basal ganglia networks are rare. We recorded electrocorticographic signals in the cortex synchronously with single units in the basal ganglia during awake neurosurgeries where subjects spoke syllable repetitions. We discovered that individual STN neurons have transient (200ms) spike-phase coupl  ...[more]

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