Spike-phase coupling of subthalamic neurons to posterior opercular cortex predicts speech sound accuracy.

ABSTRACT: Speech provides a rich context for understanding how cortical interactions with the basal ganglia contribute to unique human behaviors, but opportunities for direct intracranial recordings across cortical-basal ganglia networks are rare. We recorded electrocorticographic signals in the cortex synchronously with single units in the basal ganglia during awake neurosurgeries where subjects spoke syllable repetitions. We discovered that individual STN neurons have transient (200ms) spike-phase coupling (SPC) events with multiple cortical regions. The spike timing of STN neurons was coordinated with the phase of theta-alpha oscillations in the posterior supramarginal and superior temporal gyrus during speech planning and production. Speech sound errors occurred when this STN-cortical interactio

SUBMITTER: Vissani M 

PROVIDER: S-EPMC10614892 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature