The unique face of anxious depression: Increased sustained threat circuitry response during fear acquisition.

ABSTRACT:

Background

Sensitivity to threat with dysregulation of fear learning is thought to contribute to the development of psychiatric disorders, including anxiety disorders (AD) and major depressive disorder (MDD). However, fewer studies have examined fear learning in MDD than in AD. Nearly half of individuals with MDD have an AD and the comorbid diagnosis has worse outcomes. The current study used propensity matching to examine the hypothesis that AD+MDD shows greater neural correlates of fear learning than MDD, suggesting that the co-occurrence of AD+MDD is exemplified by exaggerated defense related processes.

Methods

195 individuals with MDD (N = 65) or AD+MDD (N=130) were recruited from the community and completed multi-level assessments, including a Pavlovian fear learning ta

SUBMITTER: Poplin T 

PROVIDER: S-EPMC10614928 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature