Complexity reduction by symmetry: uncovering the minimal regulatory network for logical computation in bacteria.

ABSTRACT: Symmetry principles play an important role in geometry, and physics, allowing for the reduction of complicated systems to simpler, more comprehensible models that preserve the system's features of interest. Biological systems are often highly complex and may consist of a large number of interacting parts. Using symmetry fibrations, the relevant symmetries for biological "message-passing" networks, we introduce a scheme, called Complexity Reduction by Symmetry or ComSym, to reduce the gene regulatory networks of Escherichia coli and Bacillus subtilis bacteria to core networks in a way that preserves the dynamics and uncovers the computational capabilities of the network. Gene nodes in the original network that share isomorphic input trees are collapsed by the fibration into eq

SUBMITTER: Alvarez-Garcia LA 

PROVIDER: S-EPMC10614959 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature