Neuroinflammation in post-acute sequelae of COVID-19 (PASC) as assessed by [¹¹C]PBR28 PET correlates with vascular disease measures.

ABSTRACT: The COVID-19 pandemic caused by SARS-CoV-2 has triggered a consequential public health crisis of post-acute sequelae of COVID-19 (PASC), sometimes referred to as long COVID. The mechanisms of the heterogeneous persistent symptoms and signs that comprise PASC are under investigation, and several studies have pointed to the central nervous and vascular systems as being potential sites of dysfunction. In the current study, we recruited individuals with PASC with diverse symptoms, and examined the relationship between neuroinflammation and circulating markers of vascular dysfunction. We used [¹¹C]PBR28 PET neuroimaging, a marker of neuroinflammation, to compare 12 PASC individuals versus 43 normative healthy controls. We found significantly increased neuroinflammation in PASC versus

SUBMITTER: VanElzakker MB 

PROVIDER: S-EPMC10614970 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature