Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival.

ABSTRACT: Glioma is a highly fatal brain tumor comprised of molecular subtypes with distinct clinical trajectories. Observational studies have suggested that variability in immune response may play a role in glioma etiology. However, their findings have been inconsistent and susceptible to reverse causation due to treatment effects and the immunosuppressive nature of glioma. We applied genetic variants associated (p<5×10^-8) with blood cell traits to a meta-analysis of 3418 glioma cases and 8156 controls. Genetically predicted increase in the platelet to lymphocyte ratio (PLR) was associated with an increased risk of glioma (odds ratio (OR)=1.25, p=0.005), especially in IDH-mutant (IDH_mut OR=1.38, p=0.007) and IDH_mut 1p/19q non-codeleted (IDH_mut-noncodel OR

SUBMITTER: Kachuri L 

PROVIDER: S-EPMC10614986 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature