Biomarkers of bleeding and venous thromboembolism in patients with acute leukemia.

ABSTRACT:

Background

Coagulopathy and associated bleeding and venous thromboembolism (VTE) are major causes of morbidity and mortality in patients with acute leukemia. The underlying mechanisms of these complications have not been fully elucidated.

Objectives

To evaluate the associations between biomarker levels and bleeding and VTE in acute leukemia patients.

Patients/method

We examined plasma levels of activators, inhibitors and biomarkers of the coagulation and fibrinolytic pathways in patients ≥18 years with newly diagnosed acute leukemia compared to healthy controls. Multivariable regression models were used to examine the association of biomarkers with bleeding and VTE in acute leukemia patients. The study included 358 patients with acute leukemia (29 acute promyelocytic

SUBMITTER: Hisada Y 

PROVIDER: S-EPMC10615001 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature